منابع مشابه
Anti-HIV Activities of Intramolecular G4 and Non-G4 Oligonucleotides.
New natural and chemically modified DNA aptamers that inhibit HIV-1 activity at submicromolar concentrations (presumably via preventing viral entry into target cells) are reported. The new DNA aptamers were developed based on known intramolecular G-quadruplexes (G4s) that were functionally unrelated to HIV inhibition [the thrombin-binding aptamer and the fragment of the human oncogene promoter ...
متن کاملG4 Resolvase 1 tightly binds and unwinds unimolecular G4-DNA
It has been previously shown that the DHX36 gene product, G4R1/RHAU, tightly binds tetramolecular G4-DNA with high affinity and resolves these structures into single strands. Here, we test the ability of G4R1/RHAU to bind and unwind unimolecular G4-DNA. Gel mobility shift assays were used to measure the binding affinity of G4R1/RHAU for unimolecular G4-DNA-formed sequences from the Zic1 gene an...
متن کاملThe G4 Genome
Recent experiments provide fascinating examples of how G4 DNA and G4 RNA structures--aka quadruplexes--may contribute to normal biology and to genomic pathologies. Quadruplexes are transient and therefore difficult to identify directly in living cells, which initially caused skepticism regarding not only their biological relevance but even their existence. There is now compelling evidence for f...
متن کاملG4-associated human diseases.
Recent research has established clear connections between G-quadruplexes and human disease. Features of quadruplex structures that promote genomic instability have been determined. Quadruplexes have been identified as transcriptional, translational and epigenetic regulatory targets of factors associated with human genetic disease. An expandable GGGGCC motif that can adopt a G4 structure, locate...
متن کاملImmunoglobulin G4 and related diseases.
i mmunoglobulins, produced by plasma cells, are the effector arm of the humoral immune system [1]. Each immunoglobulin consists of two identical heavy chains (α, β, γ, δ or ε – all encoded by chromosome 14) and two identical light chains (either κ or λ, encoded by chromosome 2 and 22, respectively) [2]. The immunoglobulins have constant (C) regions (similar within the same isotype) and variable...
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ژورنال
عنوان ژورنال: Arthropod Management Tests
سال: 2012
ISSN: 2155-9856
DOI: 10.4182/amt.2012.g4